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Potent suppressive effect of green tea polyphenols on
tobacco-induced mutagenicity.
Antimutagenic activity of green tea (Camellia sinensis) was studied using Salmonella
typhimurium strains (TA 102) (Ames test). Aqueous tobacco extract was found to be
mutagenic to S. typhimurium TA 102 at concentration of 50 mg/plate. Green tea
polyphenols was found to inhibit the mutagenicity of tobacco in a
concentration-dependent manner. Concentrations needed for 50% inhibition of
mutagen-induced revertant formation was found to be 5 mg/plate. Green tea
polyphenols was also found to inhibit the urinary mutagenicity in rats induced by
tobacco extract. Moreover green tea polyphenols were found to inhibit in vitro
nitrosation reaction produced by reaction sodium nitrite and methyl urea and further
inhibition of mutagenicity indicating that green tea has dual action to bring out a
reduction in the mutagenic and carcinogenic potential of tobacco.
Santhosh KT, Swarnam J, Ramadasan K.
Amala Cancer Research Centre, Thrissur, Kerala 680553, India.
tobacco-induced mutagenicity.
Antimutagenic activity of green tea (Camellia sinensis) was studied using Salmonella
typhimurium strains (TA 102) (Ames test). Aqueous tobacco extract was found to be
mutagenic to S. typhimurium TA 102 at concentration of 50 mg/plate. Green tea
polyphenols was found to inhibit the mutagenicity of tobacco in a
concentration-dependent manner. Concentrations needed for 50% inhibition of
mutagen-induced revertant formation was found to be 5 mg/plate. Green tea
polyphenols was also found to inhibit the urinary mutagenicity in rats induced by
tobacco extract. Moreover green tea polyphenols were found to inhibit in vitro
nitrosation reaction produced by reaction sodium nitrite and methyl urea and further
inhibition of mutagenicity indicating that green tea has dual action to bring out a
reduction in the mutagenic and carcinogenic potential of tobacco.
Santhosh KT, Swarnam J, Ramadasan K.
Amala Cancer Research Centre, Thrissur, Kerala 680553, India.
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